Several former Iowa State players showcased their talents in NFL Week 16, with Brock Purdy of the San Francisco 49ers leading the way despite a loss to the Miami Dolphins. He threw for 313 yards and two touchdowns, while also rushing for 26 yards.

Breece Hall of the New York Jets continued his impressive return from injury, contributing significantly against the Los Angeles Rams. Other notable performances included Will McDonald IV and Allen Lazard, both also from the Jets.